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1

Detection and quantification of a mycorrhization helper bacterium and a mycorrhizal fungus in plant-soil microcosms at different levels of complexity

Kurth, Florence, Zeitler, Katharina, Feldhahn, Lasse, Neu, Thomas R, Weber, Tilmann, Krištůfek, Václav, Wubet, Tesfaye, Herrmann, Sylvie, Buscot, François, Tarkka, Mika T

Journal:

BMC Microbiology

Year:

2013

Language:

english

File:

PDF, 1.28 MB

english, 2013

2

Omics and multi-omics approaches to study the biosynthesis of secondary metabolites in microorganisms

Palazzotto, Emilia, Weber, Tilmann

Journal:

Current Opinion in Microbiology

Year:

2018

Language:

english

File:

PDF, 767 KB

english, 2018

3

CRISPR/Cas-based genome engineering in natural product discovery

Tong, Yaojun, Weber, Tilmann, Lee, Sang Yup

Journal:

Natural Product Reports

Year:

2019

Language:

english

File:

PDF, 1.13 MB

english, 2019

4

Differential proteomic analysis reveals novel links between primary metabolism and antibiotic production in Amycolatopsis balhimycina

Giuseppe Gallo, Giovanni Renzone, Rosa Alduina, Efthimia Stegmann, Tilmann Weber, Anna Eliasson Lantz, Jette Thykaer, Fabio Sangiorgi, Andrea Scaloni, Anna Maria Puglia

Journal:

Year:

2010

Language:

english

File:

PDF, 1023 KB

english, 2010

5

Comparative analysis and insights into the evolution of gene clusters for glycopeptide antibiotic biosynthesis

Stefano Donadio, Margherita Sosio, Evi Stegmann, Tilmann Weber, Wolfgang Wohlleben

Journal:

Molecular Genetics and Genomics

Year:

2005

Language:

english

File:

PDF, 536 KB

english, 2005

6

The kirromycin gene cluster of Streptomyces collinus Tü 365 codes for an aspartate-α-decarboxylase, KirD, which is involved in the biosynthesis of the precursor β-alanine

Laiple, Kristina J, Härtner, Thomas, Fiedler, Hans-Peter, Wohlleben, Wolfgang, Weber, Tilmann

Journal:

The Journal of Antibiotics

Year:

2009

Language:

english

File:

PDF, 187 KB

english, 2009

7

antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

Weber, Tilmann, Blin, Kai, Duddela, Srikanth, Krug, Daniel, Kim, Hyun Uk, Bruccoleri, Robert, Lee, Sang Yup, Fischbach, Michael A., Müller, Rolf, Wohlleben, Wolfgang, Breitling, Rainer, Takano, Eriko,

Journal:

Nucleic Acids Research

Year:

2015

Language:

english

File:

PDF, 2.15 MB

english, 2015

8

Introduction to the Special Issue “Bioinformatic tools and approaches for Synthetic Biology of natural products”

Journal:

Synthetic and Systems Biotechnology

Year:

2016

Language:

english

File:

PDF, 263 KB

english, 2016

9

The Antibiotic Resistant Target Seeker (ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery

Alanjary, Mohammad, Kronmiller, Brent, Adamek, Martina, Blin, Kai, Weber, Tilmann, Huson, Daniel, Philmus, Benjamin, Ziemert, Nadine

Journal:

Nucleic Acids Research

Year:

2017

Language:

english

File:

PDF, 2.33 MB

english, 2017

10

Genome-scale metabolic reconstruction of actinomycetes for antibiotics production

Mohite, Omkar S., Weber, Tilmann, Kim, Hyun Uk, Lee, Sang Yup

Journal:

Biotechnology Journal

Year:

2018

Language:

english

File:

PDF, 531 KB

english, 2018

11

Complete Genome Sequences of 13 Bacillus subtilis Soil Isolates for Studying Secondary Metabolite Diversity

Kiesewalter, Heiko T., Lozano-Andrade, Carlos N., MarÃ³ti, Gergely, Snyder, Dan, Cooper, Vaughn S., JÃ¸rgensen, Tue Sparholt, Weber, Tilmann, KovÃ¡cs, Ãkos T., Newton, Irene L. G.

Journal:

Microbiology Resource Announcements

Year:

2020

File:

PDF, 188 KB

2020

12

Designing sgRNAs for CRISPR-BEST base editing applications with CRISPy-web 2.0

Blin, Kai, Shaw, Simon, Tong, Yaojun, Weber, Tilmann

Journal:

Synthetic and Systems Biotechnology

Year:

2020

File:

PDF, 989 KB

2020

13

CRISPRâCas9, CRISPRi and CRISPR-BEST-mediated genetic manipulation in streptomycetes

Tong, Yaojun, Whitford, Christopher M., Blin, Kai, JÃ¸rgensen, Tue S., Weber, Tilmann, Lee, Sang Yup

Journal:

Nature Protocols

Year:

2020

File:

PDF, 2.98 MB

2020

14

Module Extension of a Non-Ribosomal Peptide Synthetase of the Glycopeptide Antibiotic Balhimycin Produced by Amycolatopsis balhimycina

Diane Butz, Timo Schmiederer, Bianka Hadatsch, Wolfgang Wohlleben, Tilmann Weber, Roderich D. Süssmuth

Journal:

Year:

2008

Language:

english

File:

PDF, 852 KB

english, 2008

15

Molecular Analysis of the Kirromycin Biosynthetic Gene Cluster Revealed β-Alanine as Precursor of the Pyridone Moiety

Tilmann Weber, Kristina Juliane Laiple, Eva Karoline Pross, Adriana Textor, Stephanie Grond, Katrin Welzel, Stefan Pelzer, Andreas Vente, Wolfgang Wohlleben

Journal:

Chemistry & Biology

Year:

2008

Language:

english

File:

PDF, 916 KB

english, 2008

16

Making E. coli an Erythromycin Production Plant

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 67 KB

english, 2010

17

Supramolecular Templating in Kirromycin Biosynthesis: The Acyltransferase KirCII Loads Ethylmalonyl-CoA Extender onto a Specific ACP of the trans-AT PKS

Ewa M. Musiol, Thomas Härtner, Andreas Kulik, Jana Moldenhauer, Jörn Piel, Wolfgang Wohlleben, Tilmann Weber

Journal:

Chemistry & Biology

Year:

2011

Language:

english

File:

PDF, 402 KB

english, 2011

18

Increased glycopeptide production after overexpression of shikimate pathway genes being part of the balhimycin biosynthetic gene cluster

Jette Thykaer, Jens Nielsen, Wolfgang Wohlleben, Tilmann Weber, Michael Gutknecht, Anna E. Lantz, Evi Stegmann

Journal:

Metabolic Engineering

Year:

2010

Language:

english

File:

PDF, 259 KB

english, 2010

19

Genome mining in Amycolatopsis balhimycina for ferredoxins capable of supporting cytochrome P450 enzymes involved in glycopeptide antibiotic biosynthesis

Nina Geib, Tilmann Weber, Tanja Wörtz, Katja Zerbe, Wolfgang Wohlleben, John A. Robinson

Journal:

FEMS Microbiology Letters

Year:

2010

Language:

english

File:

PDF, 381 KB

english, 2010

20

The phosphopantetheinyl transferase KirP activates the ACP and PCP domains of the kirromycin NRPS/PKS of Streptomyces collinus Tü 365

Marina Pavlidou, Eva Karoline Pross, Ewa Maria Musiol, Andreas Kulik, Wolfgang Wohlleben, Tilmann Weber

Journal:

FEMS Microbiology Letters

Year:

2011

Language:

english

File:

PDF, 345 KB

english, 2011

21

10.1038/35016054

Kind, R., Li, X., Priestley, K., Sobolev, S. V., Tilmann, F., Yuan, X., Weber, M.

Journal:

Year:

2000

Language:

english

File:

PDF, 451 KB

english, 2000

22

Genome-scale metabolic representation of Amycolatopsis balhimycina

Wanwipa Vongsangnak, Luís Filipe Figueiredo, Jochen Förster, Tilmann Weber, Jette Thykaer, Evi Stegmann, Wolfgang Wohlleben, Jens Nielsen

Journal:

Biotechnology and Bioengineering

Year:

2012

Language:

english

File:

PDF, 223 KB

english, 2012

23

Synthetic Biology of secondary metabolite biosynthesis in actinomycetes: Engineering precursor supply as a way to optimize antibiotic production

Wolfgang Wohlleben, Yvonne Mast, Günther Muth, Marlene Röttgen, Evi Stegmann, Tilmann Weber

Journal:

Year:

2012

Language:

english

File:

PDF, 504 KB

english, 2012

24

Characterization of the ‘pristinamycin supercluster’ of Streptomyces pristinaespiralis

Yvonne Mast, Tilmann Weber, Melanie Gölz, Regina Ort-Winklbauer, Anne Gondran, Wolfgang Wohlleben, Eva Schinko

Journal:

Microbial Biotechnology

Year:

2011

Language:

english

File:

PDF, 926 KB

english, 2011

25

Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution

Christian Rausch, Ilka Hoof, Tilmann Weber, Wolfgang Wohlleben, Daniel H Huson

Journal:

BMC Evolutionary Biology

Year:

2007

Language:

english

File:

PDF, 522 KB

english, 2007

26

S100P, a novel Ca2+ -binding protein from human placenta : cDNA cloning, recombinant protein expression and Ca2+ binding properties

Tilmann BECKER, Volker GERKE, Eckhard KUBE, Klaus WEBER

Journal:

Year:

1992

Language:

english

File:

PDF, 804 KB

english, 1992

27

Isolation of the lysolipin gene cluster of Streptomyces tendae Tü 4042

Patricio Lopez, Andreas Hornung, Katrin Welzel, Claudia Unsin, Wolfgang Wohlleben, Tilmann Weber, Stefan Pelzer

Journal:

Year:

2010

Language:

english

File:

PDF, 729 KB

english, 2010

28

Discrete acyltransferases involved in polyketide biosynthesis

Musiol, Ewa Maria, Weber, Tilmann

Journal:

Year:

2012

Language:

english

File:

PDF, 1.06 MB

english, 2012

29

Switching of a coupled spin pair in a single-molecule junction

Wagner, Stefan, Kisslinger, Ferdinand, Ballmann, Stefan, Schramm, Frank, Chandrasekar, Rajadurai, Bodenstein, Tilmann, Fuhr, Olaf, Secker, Daniel, Fink, Karin, Ruben, Mario, Weber, Heiko B.

Journal:

Nature Nanotechnology

Year:

2013

Language:

english

File:

PDF, 1.24 MB

english, 2013

30

The AT 2 Domain of KirCI Loads Malonyl Extender Units to the ACPs of the Kirromycin PKS

Musiol, Ewa Maria, Greule, Anja, Härtner, Thomas, Kulik, Andreas, Wohlleben, Wolfgang, Weber, Tilmann

Journal:

Year:

2013

Language:

english

File:

PDF, 649 KB

english, 2013

31

In silico tools for the analysis of antibiotic biosynthetic pathways

Journal:

International Journal of Medical Microbiology

Year:

2014

Language:

english

File:

PDF, 1020 KB

english, 2014

32

Reprogramming Acyl Carrier Protein Interactions of an Acyl-CoA Promiscuous trans-Acyltransferase

Ye, Zhixia, Musiol, Ewa M., Weber, Tilmann, Williams, Gavin J.

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 2.62 MB

english, 2014

33

Biosynthesis of Phenylnannolone A, a Multidrug Resistance Reversal Agent from the Halotolerant Myxobacterium Nannocystis pusilla B150

Bouhired, Sarah M., Crüsemann, Max, Almeida, Celso, Weber, Tilmann, Piel, Jörn, Schäberle, Till F., König, Gabriele M.

Journal:

Year:

2014

Language:

english

File:

PDF, 645 KB

english, 2014

34

Poly Specific trans -Acyltransferase Machinery Revealed via Engineered Acyl-CoA Synthetases

Koryakina, Irina, McArthur, John, Randall, Shan, Draelos, Matthew M., Musiol, Ewa M., Muddiman, David C., Weber, Tilmann, Williams, Gavin J.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.73 MB

english, 2013

35

Complete genome sequence of the actinobacterium Amycolatopsis japonica MG417-CF17T (=DSM 44213T) producing (S,S)-N,N′-ethylenediaminedisuccinic acid

Stegmann, Evi, Albersmeier, Andreas, Spohn, Marius, Gert, Helena, Weber, Tilmann, Wohlleben, Wolfgang, Kalinowski, Jörn, Rückert, Christian

Journal:

Journal of Biotechnology

Year:

2014

Language:

english

File:

PDF, 251 KB

english, 2014

36

Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes

Weber, Tilmann, Charusanti, Pep, Musiol-Kroll, Ewa Maria, Jiang, Xinglin, Tong, Yaojun, Kim, Hyun Uk, Lee, Sang Yup

Journal:

Trends in Biotechnology

Year:

2015

Language:

english

File:

PDF, 1.13 MB

english, 2015

37

Novel Amycolatopsis balhimycina biochemical abilities unveiled by proteomics

Alduina, Rosa, Gallo, Giuseppe, Renzone, Gianni, Weber, Tilmann, Scaloni, Andrea, Puglia, Anna M.

Journal:

FEMS Microbiology Letters

Year:

2014

Language:

english

File:

PDF, 199 KB

english, 2014

38

CRISPR-Cas9 Based Engineering of Actinomycetal Genomes

Tong, Yaojun, Charusanti, Pep, Zhang, Lixin, Weber, Tilmann, Lee, Sang Yup

Journal:

ACS Synthetic Biology

Year:

2015

Language:

english

File:

PDF, 1.27 MB

english, 2015

39

Identification and activation of novel biosynthetic gene clusters by genome mining in the kirromycin producerStreptomyces collinusTü 365

Iftime, Dumitrita, Kulik, Andreas, Härtner, Thomas, Rohrer, Sabrina, Niedermeyer, Timo Horst Johannes, Stegmann, Evi, Weber, Tilmann, Wohlleben, Wolfgang

Journal:

Journal of Industrial Microbiology & Biotechnology

Year:

2016

Language:

english

File:

PDF, 1.10 MB

english, 2016

40

The secondary metabolite bioinformatics portal: Computational tools to facilitate synthetic biology of secondary metabolite production

Weber, Tilmann, Kim, Hyun Uk

Journal:

Synthetic and Systems Biotechnology

Year:

2016

Language:

english

File:

PDF, 1.76 MB

english, 2016

41

CRISPy-web: An online resource to design sgRNAs for CRISPR applications

Blin, Kai, Pedersen, Lasse Ebdrup, Weber, Tilmann, Lee, Sang Yup

Journal:

Synthetic and Systems Biotechnology

Year:

2016

Language:

english

File:

PDF, 932 KB

english, 2016

42

Metabolic engineering with systems biology tools to optimize production of prokaryotic secondary metabolites

Kim, Hyun Uk, Charusanti, Pep, Lee, Sang Yup, Weber, Tilmann

Journal:

Natural Product Reports

Year:

2016

Language:

english

File:

PDF, 705 KB

english, 2016

43

Elucidating the molecular physiology of lantibiotic NAI-107 production in Microbispora ATCC-PTA-5024

Gallo, Giuseppe, Renzone, Giovanni, Palazzotto, Emilia, Monciardini, Paolo, Arena, Simona, Faddetta, Teresa, Giardina, Anna, Alduina, Rosa, Weber, Tilmann, Sangiorgi, Fabio, Russo, Alessandro, Spinell

Journal:

Year:

2016

Language:

english

File:

PDF, 1.84 MB

english, 2016

44

The evolution of genome mining in microbes – a review

Ziemert, Nadine, Alanjary, Mohammad, Weber, Tilmann

Journal:

Natural Product Reports

Year:

2016

Language:

english

File:

PDF, 943 KB

english, 2016

45

Streptocollin, a Type IV Lanthipeptide Produced by Streptomyces collinus Tü 365

Iftime, Dumitrita, Jasyk, Martin, Kulik, Andreas, Imhoff, Johannes F., Stegmann, Evi, Wohlleben, Wolfgang, Süssmuth, Roderich D., Weber, Tilmann

Journal:

Year:

2015

Language:

english

File:

PDF, 5.83 MB

english, 2015

46

The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters

Blin, Kai, Medema, Marnix H., Kottmann, Renzo, Lee, Sang Yup, Weber, Tilmann

Journal:

Nucleic Acids Research

Year:

2016

Language:

english

File:

PDF, 1.34 MB

english, 2016

47

Dissemination of antibiotic resistance genes from antibiotic producers to pathogens

Jiang, Xinglin, Ellabaan, Mostafa M. Hashim, Charusanti, Pep, Munck, Christian, Blin, Kai, Tong, Yaojun, Weber, Tilmann, Sommer, Morten O. A., Lee, Sang Yup

Journal:

Nature Communications

Year:

2017

Language:

english

File:

PDF, 935 KB

english, 2017

48

Linking secondary metabolites to biosynthesis genes in the fungal endophyte Cyanodermella asteris : The anti-cancer bisanthraquinone skyrin

Jahn, Linda, Schafhauser, Thomas, Wibberg, Daniel, Rückert, Christian, Winkler, Anika, Kulik, Andreas, Weber, Tilmann, Flor, Liane, van Pée, Karl-Heinz, Kalinowski, Jörn, Ludwig-Müller, Jutta, Wohlleb

Journal:

Journal of Biotechnology

Year:

2017

Language:

english

File:

PDF, 760 KB

english, 2017

49

Towards systems metabolic engineering of streptomycetes for secondary metabolites production

Robertsen, Helene Lunde, Weber, Tilmann, Kim, Hyun Uk, Lee, Sang Yup

Journal:

Biotechnology Journal

Year:

2017

Language:

english

File:

PDF, 811 KB

english, 2017

50

Recent development of computational resources for new antibiotics discovery

Kim, Hyun Uk, Blin, Kai, Lee, Sang Yup, Weber, Tilmann

Journal:

Current Opinion in Microbiology

Year:

2017

Language:

english

File:

PDF, 569 KB

english, 2017